Mutations Worksheet Deletion Insertion And Substitution Answers. A substitution mutation in that gene causes the amino acid valine to be incorporated into hemoglobin in a place where glutamic acid would normally lie. When a nucleotide is wrongly inserted or deleted from a codon, the affects can be drastic.

Insertions and Deletion mutations are often together dubbed as INDELS.
Insertion or deletion results in a frame-shift that changes the reading of subsequent codons and, therefore, alters the entire amino acid sequence that follows the mutation, insertions and deletions are usually more harmful than a substitution in which only a single amino acid is altered.
Substitution -- a nucleotide replaces another. SUBSTITUTION (one base is substituted for another) --- If a substitution changes the amino acid, it's called a MISSENSE mutation Classify each as Deletion, Insertion or Substitution AND as either frameshift, missense, silent or nonsense (Hint: Deletion & Insertion will always be frameshift). A deletion mutation is a mistake in the DNA replication process which removes nucleotides from the genome.